Polymer Translocation Induced by Adsorption
نویسنده
چکیده
We study the translocation of a flexible polymer through a pore in a membrane induced by its adsorption on trans side of the membrane. When temperature T is higher than Tc, the adsorption-desorption transition temperature, attractive interaction between polymer and membrane plays little role in affecting polymer conformation, leading to translocation time that scales as τ ∼ L3 where L is the polymer contour length. When T < Tc, however, the translocation time undergoes a sharp crossover to τ ∼ L2 for sufficiently long polymers, following the second order conformational (adsorption) transition. The translocation time is found to exhibit the crossover around T = T ′ c, which is lower than Tc for polymers shorter than a critical length(N < Nc).
منابع مشابه
Homo-polymers with balanced hydrophobicity translocate through lipid bilayers and enhance local solvent permeability
Recent experimental studies indicate that polymeric structures with a well-adjusted balance of amphiphilic parts may translocate through self-assembled phospholipid bilayers and enhance the passive trans-membrane transport of smaller molecules. Using a coarse grained lattice Monte Carlo model with explicit solvent we investigate self-assembled lipid bilayers interacting with a linear polymer ch...
متن کاملAdsorption-driven translocation of polymer chain into nanopores.
The polymer translocation into nanopores is generally facilitated by external driving forces, such as electric or hydrodynamic fields, to compensate for entropic restrictions imposed by the confinement. We investigate the dynamics of translocation driven by polymer adsorption to the confining walls that is relevant to chromatographic separation of macromolecules. By using the self-consistent fi...
متن کاملTranslocation dynamics of freely jointed Lennard-Jones chains into adsorbing pores.
Polymer translocation into adsorbing nanopores is studied by using the Fokker-Planck equation of chain diffusion along the energy landscape calculated with Monte Carlo simulations using the incremental gauge cell method. The free energy profile of a translocating chain was found by combining two independent sub-chains, one free but tethered to a hard wall, and the other tethered inside an adsor...
متن کاملNon-equilibrium dynamics of single polymer adsorption to solid surfaces.
The adsorption of polymers to surfaces is crucial for understanding many fundamental processes in nature. Recent experimental studies indicate that the adsorption dynamics is dominated by non-equilibrium effects. We investigate the adsorption of a single polymer of length N to a planar solid surface in the absence of hydrodynamic interactions. We find that for weak adsorption energies the adsor...
متن کاملPolymer capture by electro-osmotic flow of oppositely charged nanopores.
The authors have addressed theoretically the hydrodynamic effect on the translocation of DNA through nanopores. They consider the cases of nanopore surface charge being opposite to the charge of the translocating polymer. The authors show that, because of the high electric field across the nanopore in DNA translocation experiments, electro-osmotic flow is able to create an absorbing region comp...
متن کامل